pentobarbital improves toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. CYP3A4 inducers may raise the metabolism of ifosfamide to its Lively alkylating metabolites. pentobarbital will minimize the level or impact of alosetron by impacting hepatic enzyme CYP2C9/10 metabolism. Minimal/Signific